Proteins comprise a significant percentage of body structures in all living organisms on Earth. Proteins make up various structures of the human body, from the smallest like hair and nails to the more complex ones like muscles. Proteins are made of sequences of molecules known as amino acids. Amino acids are divided into two groups: non-essential amino acids, which the body is able to synthesize and essential amino acids, which the body has to obtain from dietary sources since we cannot make them naturally.

BCAAS is one of the nine groups of essential proteins in humans that make up to 35% of the amino acids required for the synthesis of muscle proteins. BCAAs refer to Branched Amino Acids, that is a group of amino acids comprising of Leucine, Valine and Isoleucine in the ratio of 2:1:1 respectively. They are called branched as they are the only amino acids with a branched side chain. BCAAs are essential in the body as they help stimulate the synthesis of protein in muscle, act as an energy source and also reduce muscle protein breakdown.

So how do BCAAs do it? The activity of BCAAs 2:1:1 and protein synthesis depends primarily on Leucine. Leucine is a vital component of the muscle protein synthesis process and works by enhancing anabolic signaling through directly or indirectly (via insulin) activating a protein known as Target of Rapamycin (TOR). The TOR pathway once activated by dietary Leucine induces the synthesis of muscle proteins. Isoleucine increases the body’s ability to uptake glucose, which, when broken down acts as a source of energy.

Exercise leads to a decline in serum levels, causing an influx of the amino acid tryptophan into the brain and a subsequent increase in serotonin levels. According to scientists, the upsurge of serotonin levels is thought to cause fatigue. BCAAs reduce fatigue and improve performance through preventing serum decline and consequently reducing serotonin levels. Although the ability of BCAAs to enhance performance is contested by some groups of scientists, their ability to reduce muscle breakdown is an accepted fact among medics and scientists alike.

When metabolized, BCAA protein supplements promote anabolic hormone profile that causes muscle repairs after intense workouts. Scientific studies show that taking BCAA supplements recovers peripheral blood mononuclear cell proliferation in addition to producing plasma glutamine concentration after an exercise. Scientists also believe that the ingestion of BCAA supplements after exercise suppresses the proteins involved in muscle atrophy or breakdown. Subsequently, athletes and sports people who take BCAAs do not experience much of the post-workout soreness associated with muscle wastage and repair.

Consequently, Branched Amino Acids have numerous applications in medicine and sports science. They are used to treat slow muscle wasting and amyotrophic lateral sclerosis among others. Most importantly, BCAAs are used in sports nutrition to develop mass, especially when on a calorie deficit diet. In addition, they help with muscle building and repair, enhance performance and reduce fatigue. It is important to note that the metabolism of Branched Chain Amino Acids takes place in the skeletal muscles, a contrast to other amino acids whose breakdown occurs in the liver. Hence, metabolism of BCAAs is quick and efficient, a characteristic that favors anyone in an intense exercise program.

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Betaine Anhydrous (Trimethylglycine) is a naturally occurring amino acid type vitamin in the human body. It is also abundant in plant sources such as beetroot, spinach, broccoli, some wheat sources, and also in shellfish. Its primary purpose in the body is to regulate the levels of homocysteine, an amino acid useful in cellular metabolism and protein synthesis. However, its elevated concentrations in the body can result in conditions such as cardiovascular thrombosis, ocular deformities, osteoporosis, skeletal abnormalities, and atherosclerosis. Betaine Anhydrous is taken orally in the form of a powder and is more effective when combined with other compounds such as vitamin B12, choline, and folic acid.

Uses and Benefits of Betaine Anhydrous

· Bodybuilding and Composition (workout)
The bodybuilding Trimethylglycine function occurs through the methylation of homocysteine to form methionine. Methylation is the process where a methyl group combines with adenine or cytosine in DNA nucleotides. Human body requires methionine to produce creatine, an amino acid that boosts muscle strength and size. This action helps to increase the overall workout intensity and ensure you achieve a higher level of muscle mass. Betaine Anhydrous is of great benefit to individuals who find it a challenge to maintain enough volume in their workout plan.

This supplement will also help you to train in your bodybuilding program at a higher frequency, meaning more muscular gains at a very short time. The more frequent you stimulate your muscle, the faster they will grow. In addition, this action increases the muscle recovery rates, which means you will not need much time to rest in between your workout program.

Betaine Anhydrous also helps in improving strength in individuals suffering from muscular dystrophy. Muscular dystrophy is a collection of genetic diseases characterized by weakness and degeneration of voluntary or skeletal muscles, which controls movement.

· Helpful in weight loss

Studies indicate that Betaine Anhydrous is lipotropic, which means that it promotes the oxidation of lipids. This action helps your body to utilize the already stored fat in the production of energy and other bodily functions. It also boosts the metabolism, which is vital for muscle formation and body fat burning.

· Mental health

This supplement is also beneficial for mental function and mood enhancement through balancing the levels of cortisol, the hormone that is responsible for stress. It also helps in the production of dopamine, serotonin, and norepinephrine. These are essential neurotransmitters in the brain and responsible for depression, sleep and proper functioning of the central nervous system.

· Other functions

In human body, Betaine Anhydrous is essential in maintaining the digestive system, protecting the kidney from damage, facilitating cell production, and helps in DNA formation. These roles facilitate proper digestion and absorption of food in the alimentary canal, removal of wastes products from the body, and transmission of genetic information to various parts of the body.

Other additional information

People of all ages, who are free of medical complications and are of good health can benefit from what this supplement offers. It is recommended to take it mainly during stressful moments since this is the time its levels in the body may be insufficient. Symptoms of Betaine Anhydrous deficiencies  include impaired cell production, unstable homocysteine levels, decreased immunity and compromised liver and gastrointestinal function. The dosage depends on your health conditions and age. It is best to follow your doctor’s prescription.


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Creatine is a molecule in the creatine phosphate system which assists in rapid production of ATP (energy molecules) in order to support cellular function of the body. A documented and researched supplement for muscle mass development, creatine has been regarded clinically safe for most people.

Creatine Compound

What Is Creatine Supplement Used For?

One of the most popular physical performance supplements, creatine has been used extensively for muscle development and increasing the power output of the skeletal muscles. Generally speaking, creatine not only helps you increase your muscle mass, but also gives you the more strength to work out.

Creatine Powder

Apart from the muscle mass development and energy boosting properties, athletes and physical fitness enthusiasts choose creatine supplements for properties of neuro-protection, anti-depressant properties in females and cognitive enhancer. Apart from these proven health benefits of creatine, creatine supplementation may also benefit in reducing the rate of cellular apoptosis, thus directly increasing longevity.


How Does Creatine Work?

Creatine is an essential part of the creatine phosphate system in which creatine phosphate and creatine accept and donate a phosphate group. The phosphate group is able to replenish other molecules that need a replacement, for example the replenishment of adenosine diphosphate (ADP) and adenosine triphosphate (ATP) which are the main sources of energy.

Hence creatine allows replenishing of ATP directly, without breaking down other molecules. Consuming creatine supplementation increases the creatine pool in the system, adding to higher rate of phosphate donation and thus aiding in replenishing the ATP molecules. This results in increased energy in the system with compromising any of the other nutrients in the body.




Are Creatine Supplements Safe?

There are no clinically proven harmful effects related to consumption of creatine supplements. Consumption of creatine has been considered safe it has no adverse effect on vital organs such as kidneys or the liver, but consumption of creatine supplements in large quantities has been regarded with a few side effects.

Since the intestinal absorption of creatine in the body is limited, consuming a large amount of creatine supplement at once can result in diarrhea. Creatine has water drawing properties which can additionally result in nausea or an upset stomach. These side effects can be easily averted by drinking ample of water when consuming creatine supplements and not consuming large amounts of creatine supplements at once.


Creatine Fitness Supplement


How Much Creatine Supplement Should Be Taken?

For a person who is not very athletic or work out just a little, creatine supplement in the dosage of 2 to 3 grams daily should suffice. Professional athletes and body building enthusiasts require a higher rate of creatine turnover in the muscle tissues. Thus a minimum of 5 grams of creatine supplement every day is the requirement for muscle mass development.  While many fitness supplements try and avoid the full amount of recommended creatine supplement to cut costs, DarkOPS PreOPS supplement (seen above) is one of the newer higher end supplements to hit the market with adequate dosage.

Although loading period is not necessarily required for creatine supplement consumption, it might be a useful practice if your body responds well to the creatine supplements. Once you start consuming creatine supplements, you may also experience gain in water weight. However, you must only follow the creatine supplement loading if your body is acceptable to it and does not result in any side effects.

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